A ring of glass ampoules of amber liquid under chrome filling nozzles, in ultraviolet light

PDRN, made without animal-derived sources

The science

A focus on building blocks the body already uses

Every cell relies on nucleotides to build and repair its DNA. Research suggests that as PDRN is broken down, its components can enter nucleotide salvage pathways—the cellular systems that recycle these building blocks for new nucleic-acid synthesis.

We are developing PDRN without animal-derived starting material, with tight control over the length of the DNA fragments we produce.

Read the research on PDRN

Glass vials of amber liquid on a turning steel plate under violet light
Defined fragment length, at scalebase pairs
Synthena PDRN
Conventional PDRN
Fragment length

A narrower, defined range

Our target fragments are 20–80 base pairs, approximately 13–53 kilodaltons. PDRN described in the scientific literature commonly spans a much broader range—approximately 80–2,200 base pairs.

Three steps01 to 03
Gloved hands grind frozen green leaf in a white mortar as cold vapour spills across the bench
1ExtractPlant cells are among the hardest biological sources to open.
A glass column clamped upright in a bright laboratory; a clear drop falls from its tip toward a beaker
2PurifyThe DNA is separated from the rest of the cell.
A sealed vial of pale amber liquid held by a clamp in a chilled bath whose surface is covered in fine, even ripples
3Standardize fragment lengthThe DNA is brought to a defined fragment length.
Process control

Control begins with how it is made

We extract the DNA, purify it and bring it to a defined fragment-length range.

We have developed our own methods around each of these three steps, giving us control from biological source to final material.

In the published research1 + 3
EstablishedAdenosine A2A receptor at the cell surface
ProposedTLR9, an endosomal DNA sensor
ProposedIntracellular DNA sensors; An emerging area of PDRN research
ProposedNucleotide salvage; PDRN breakdown products are recycled into nucleotide pools for new nucleic-acid synthesis.

Chae et al., 2025; Squadrito et al., 2017; Galeano et al., 2021.

Mechanism

Following the biology

Two routes currently have the strongest support in PDRN research: adenosine A2A receptor signaling and nucleotide salvage.

Researchers are also investigating whether DNA-sensing pathways, including TLR9 and cGAS–STING, contribute to PDRN biology.

What goes in, and what does notsources
InPlant sources
InMicrobial sources
Not inTerrestrial animal sources
Not inAquatic sources
Source and tolerability

Considered from the beginning

Our process uses plant and microbial sources, with no animal-derived starting material.

Tolerability testing begins with our earliest development batches and continues as the material advances.

Two hands in purple nitrile gloves holding a glass dish of gold culture up to a laboratory window
Source

Every batch begins with a culture

The culture is where the DNA begins—and where our control begins with it.

No animal-derived starting material enters the process. From culture through final material, each step is documented and traceable.

What stays with every batchthe record
Fragment-length distribution
Measured
Purity
Measured
Tolerability
Tested
Date, instrument and operator
Recorded
A retained sample
Kept
Control

Checked before it leaves the bench

Every batch is characterised for fragment-length distribution and purity, and undergoes defined tolerability testing before progressing further.

The results stay with the batch.

A number never stands alone. It stays connected to the date it was measured, the instrument that measured it, the operator who performed the measurement and a retained sample of the batch.

A researcher seats a small vial in a bench-top instrument in a dark laboratory, lit by the instrument's own lamp

Advancing into Five Programmes

We are evaluating the same defined PDRN approach across five areas of human biology—skin, joints, circulation, gut and nervous system. Starting with the skin.

Explore our programmes